Publications
2024
Quansah Amissah R, Kayir H, Talhat MA, Hassan A, Gu Y, Johnson R, Urban K, Khokhar, JY. Sex differences in the neural and behavioral effects of acute high-dose edible cannabis consumption in rats. Journal of Pharmacology and Experimental Therapeutics. 2024 JPET-AR-2023-001987. doi: 10.1124/jpet.123.001987.
Thorpe HHA, Fontanillas P, Pham BK, Meredith JJ, Jennings MV, Courchesne-Krak NS, Vilar-Ribó L, Bianchi SB, Mutz J, 23andMe Research Team, Elson SL, Khokhar JY, Abdellaoui A, Davis LK, Palmer AA, Sanchez-Roige S. Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations. Neuropsychopharmacology. 2024 10.1038/s41386-024-01870-x.
Kuzma-Hunt AG, Sabry R, Davis OS, Truong VB, Khokhar JY, Fabetta LA. THC and sperm: Impact on fertilization capability, pre-implantation in vitro development and epigenetic modifications. PLoS One. 2024 Mar 27; 19(3)e0298697. doi: 10.1371/journal.pone.0298697.
Frie JA, Khokhar JY. FARESHARE: An open-source apparatus for assessing drinking microstructure in socially housed rats. NPP—Digit Psychiatry Neurosci. 2024. 2:1. doi:10.1038/s44277-024-00002-z.
2023
Frie JA, McCunn P, Eed A, Hassan A, Luciani KR, Chen C, Tyndale RF, Khokhar JY. Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters. Neuropsychopharmacology. 2023 Dec 7; doi: 10.1038/s41386-023-01773-3.
Kayir H, Ruffolo J, McCunn P, Khokhar JY. The Relationship Between Canabis, Cognition, and Schizophrenia: It's Complicated. Curr Top Behav Neurosci. 2023:63:437-461. doi: 10.1007/7854_2022_396.
Quansah Amissah R, Albeely AM, Bragg EM, Perreault ML, Doucette WT, Khokhar JY. A Simple, Lightweight, and Low-Cost Customizable Multielectrode Array for Local Field Potential Recordings. eNeuro. 2023 Aug 29;10(8):ENEURO.0212-23.2023. doi: 10.1523/ENEURO.0212-23.2023.
Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T; 23andMe Research Team; Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA. CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. Transl Psychiatry. 2023 May 12;13(1):167. doi: 10.1038/s41398-023-02453-y.
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière DA, Blockx I, Bortel A, Broadwater M, Cardoso BM, Célestine M, Chavez-Negrete JE, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes FF, Fowler CF, Fuentes-Ibañez A, Garin CM, Gelderman E, Golden CEM, Guo CCG, Henckens MJAG, Hennessy LA, Herman P, Hofwijks N, Horien C, Ionescu TM, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee SH, Lillywhite A, Liu Y, Liu YY, López-Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan MJ, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens DMP, Nava-Gomez LJ, Nonaka H, Ortiz JJ, Paasonen J, Peeters LM, Pereira M, Perez PD, Pompilus M, Prior M, Rakhmatullin R, Reimann HM, Reinwald J, Del Rio RT, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten TJ, Ryoke R, Sack M, Salvan P, Sanganahalli BG, Schroeter A, Seewoo BJ, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith JAB, Smith C, Sobczak F, Stenroos PJ, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García ME, Tudela R, van den Berg M, van der Marel K, van Hout ATB, Vertullo R, Vidal B, Vrooman RM, Wang VX, Wank I, Watson DJG, Yin T, Zhang Y, Zurbruegg S, Achard S, Alcauter S, Auer DP, Barbier EL, Baudewig J, Beckmann CF, Beckmann N, Becq GJPC, Blezer ELA, Bolbos R, Boretius S, Bouvard S, Budinger E, Buxbaum JD, Cash D, Chapman V, Chuang KH, Ciobanu L, Coolen BF, Dalley JW, Dhenain M, Dijkhuizen RM, Esteban O, Faber C, Febo M, Feindel KW, Forloni G, Fouquet J, Garza-Villarreal EA, Gass N, Glennon JC, Gozzi A, Gröhn O, Harkin A, Heerschap A, Helluy X, Herfert K, Heuser A, Homberg JR, Houwing DJ, Hyder F, Ielacqua GD, Jelescu IO, Johansen-Berg H, Kaneko G, Kawashima R, Keilholz SD, Keliris GA, Kelly C, Kerskens C, Khokhar JY, Kind PC, Langlois JB, Lerch JP, López-Hidalgo MA, Manahan-Vaughan D, Marchand F, Mars RB, Marsella G, Micotti E, Muñoz-Moreno E, Near J, Niendorf T, Otte WM, Pais-Roldán P, Pan WJ, Prado-Alcalá RA, Quirarte GL, Rodger J, Rosenow T, Sampaio-Baptista C, Sartorius A, Sawiak SJ, Scheenen TWJ, Shemesh N, Shih YI, Shmuel A, Soria G, Stoop R, Thompson GJ, Till SM, Todd N, Van Der Linden A, van der Toorn A, van Tilborg GAF, Vanhove C, Veltien A, Verhoye M, Wachsmuth L, Weber-Fahr W, Wenk P, Yu X, Zerbi V, Zhang N, Zhang BB, Zimmer L, Devenyi GA, Chakravarty MM, Hess A. A consensus protocol for functional connectivity analysis in the rat brain. Nat Neurosci. 2023 Apr;26(4):673-681. doi: 10.1038/s41593-023-01286-8.
Truong VB, Davis OS, Gracey J, Neal MS, Khokhar JY, Favetta LA. Sperm capacitation and transcripts levels are altered by in vitro THC exposure. BMC Mol Cell Biol. 2023 Feb 23;24(1):6. doi: 10.1186/s12860-023-00468-3.
Dufour J, Sabry R, Khokhar JY, Favetta LA. Delta-9 tetrahydrocannabinol (THC) effects on the cortisol stress response in bovine granulosa cells. Toxicol In Vitro. 2023 Apr;88:105549. doi: 10.1016/j.tiv.2022.105549. Epub 2022 Dec 31.
Kayir H, Ruffolo J, McCunn P, Khokhar JY. The Relationship Between Cannabis, Cognition, and Schizophrenia: It's Complicated. Curr Top Behav Neurosci. 2023;63:437-461. doi: 10.1007/7854_2022_396.
Preprints
Frie JA, Khokhar JY. FARESHARE: An Open-source Apparatus for Assessing Drinking Microstructure in Socially Housed Rats. bioRxiv. 2023 Oct 9. doi: 10.1101/2023.10.06.561248.
Thorpe HHA, Fontanillas P, Pham BK, Meredith JJ, Jennings MV, Courchesne-Krak NS, Vilar-Ribó L, Bianchi SB, Mutz J, 23andMe Research Team, Elson SL, Khokhar JY, Abdellaoui A, Davis LK, Palmer AA, Sanchez-Roige S. Genome-Wide Association Studies of Coffee Intake in UK/US Participants of European Ancestry Uncover Gene-Cohort Influences. medRxiv. 2023 Sep 11. doi: 10.1101/2023.09.09.23295284.
2022
McCunn P, Chen X, Gimi B, Green AI, Khokhar JY. Glutamine and GABA alterations in cingulate cortex may underlie alcohol drinking in a rat model of co-occurring alcohol use disorder and schizophrenia: an 1H-MRS study. Schizophrenia (Heidelb). 2022 Aug 23;8(1):67. doi: 10.1038/s41537-022-00272-6.
Sikic A, Frie JA, Khokhar JY, Murray JE. Sex Differences in the Behavioural Outcomes of Prenatal Nicotine and Tobacco Exposure. Front Neurosci. 2022 Jul 8;16:921429. doi: 10.3389/fnins.2022.921429.
Henricks AM, Sullivan EDK, Dwiel LL, Li JY, Wallin DJ, Khokhar JY, Doucette WT. Maternal immune activation and adolescent alcohol exposure increase alcohol drinking and disrupt cortical-striatal-hippocampal oscillations in adult offspring. Transl Psychiatry. 2022 Jul 20;12(1):288. doi: 10.1038/s41398-022-02065-y.
Al-Sabagh Y, Thorpe HHA, Jenkins BW, Hamidullah S, Talhat MA, Suggett CB, Reitz CJ, Rasouli M, Martino TA, Khokhar JY. Rev-erbα Knockout Reduces Ethanol Consumption and Preference in Male and Female Mice. Int J Mol Sci. 2022 May 6;23(9):5197. doi: 10.3390/ijms23095197.
Doucette, W. T., Smedley, E. B., Ruiz-Jaquez, M., Khokhar, J. Y., Smith, K. S., Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet. Brain Res. 2022 June 1. https://doi.org/10.1016/j.brainres.2022.147886
Quansah Amissah, R., Vogt, N. A., Chen, C., Urban, K., Khokhar, J. Y., Prevalence and characteristics of cannabis-induced toxicoses in pets: Results from a survey of veterinarians in North America. PLoS One. 2022 April 20. https://doi.org/10.1371/journal.pone.0261909
Rizk, A. A., Jenkins, B. W., Al-Sabagh, Y., Hamidullah, S., Reitz, C. J., Rasouli, M., Martino, T. A., Khokhar, J. Y., The Impact of Sex, Circadian Disruption, and the Clock Δ19/Δ19 Genotype on Alcohol Drinking in Mice. Genes (Basel). 2022 April 15. https://doi.org/10.3390/genes13040701
Kayir, H., Jenkins, B. W., Alural, B., Khokhar, J. Y., Clozapine Increases Nestin Concentration in the Adult Male Rat Hippocampus: A Preliminary Study. Int J Mol Sci. 2022 March 22. https://doi.org/10.3390/ijms23073436
2021
Ruffolo, J., Frie, J. A., Thorpe, H. H. H., Talhat, M. A., Khokhar, J. Y., Alcohol and Vaporized Nicotine Co-Exposure During Adolescence Contribute Differentially to Sex-Specific Behavioral Effects in Adulthood. Nicotine Tob. Res. 2021 December 3. https://doi.org/10.1093/ntr/ntab250
Jenkins, B. W., Buckhalter, S., Perreault, M. L., Khokhar, J. Y., Cannabis Vapour Exposure Alters Neural Circuit Oscillatory Activity in A Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents. Schizophr. Bull. 2021 November 20. https://doi.org/10.1093/schizbullopen/sgab052
Sullivan, E. D.K., Locke, L. N., Wallin, D. J., Khokhar, J. Y., Bragg, E. M., Henricks, A. M., Doucette, W. T., The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat. Front Behav Neurosci. 2021 November 11. https://doi.org/10.3389/fnbeh.2021.760791
Frie, J. A., Nolan, C. J., Murray, J. E., Khokhar, J. Y., Addiction-Related Outcomes of Nicotine and Alcohol Co-use: New Insights Following the Rise in Vaping. Nicotine Tob Res. 2021 Nov 10. https://doi.org/10.1093/ntr/ntab231
Ellner, D., Hallam, B., Frie, J. A., Thorpe, H. H. A., Shoaib, M., Kayir, H., Jenkins, B. W., Khokhar, J. Y., Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism during Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats. Front Synaptic Neurosci. 2021 https://doi.org/10.3389/fnsyn.2021.732402
Wallin, D. J., Sullivan, E. D. K., Bragg, E. M., Khokhar, J. Y., Lu, H., Doucette, W. T., Acquisition of resting-state functional magnetic resonance imaging data in the rat. J Vis Exp. 2021 https://dx.doi.org/10.3791/62596
Buckhalter, S., Soubeyrand, E., Ferrone, S. A. E., Rasmussen, D. J., Manduca, J. D., Al-Abdul Wahid, S., Frie, J. A., Khokhar, J. Y., Akhtar, T. A., Perreault, M. L., The antidepressant-like and analgesic effects of kratom alkaloids are accompanied by changes in low frequency oscillations but not ΔFosB accumulation. Front Pharmacol 2021; 12: 696461. https://doi.org/10.3389/fphar.2021.696461
McKie, G. L., Shamshoum, H., Hunt, K. L., Thorpe, H. H. A., Dibe, H. A., Khokhar, J. Y., Doucette, C. A., Wright, D. C., Intermittent Cold Exposure Improves Glucose Homeostasis Despite Exacerbating Diet-Induced Obesity in Mice Housed at Thermoneutrality. J Physiol. 2021 Jun 30. https://doi.org/10.1113/JP281774
Theriault, R. K., St-Denis, M., Hewitt, T., Khokhar, J. Y., Lalonde, J., Perreault, M. L., Sex-specific cannabidiol- and iloperidone-induced neuronal activity changes in an in vitro MAM model system of schizophrenia. Int J Mol Sciences. 2021 May 24;22(11):5511. https://doi.org/10.3390/ijms22115511
Oleson E. B., KhokharJ. Y. Cannabinoids: Emerging developments in neuropsychopharmacology and biological psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 15:110305. https://doi.org/10.1016/j.pnpbp.2021.110305
Renda, B., Andrade, A., Stone, A. P., El Azali, R., Sharivker, M., Khokhar, J. Y., Antenos, M., Murray, J. E., Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats. Psychopharmacology 2021 Mar 1. https://doi.org/10.1007/s00213-021-05803-0
Misner, M., Taborek, A., Dufour, J., Sharifi, L., Khokhar, J. Y., Favetta, L. A., 2021, Effects of delta-9 tetrahydrocannabinol (THC) on oocyte competence and early embryonic development. Front. Toxicol. 23 March 2021 https://doi.org/10.3389/ftox.2021.647918
Jenkins, B. W., Khokhar, J. Y. 2021. Cannabis use and mental illness: understanding circuit dysfunction through preclinical models. Front. Psychiatry. https://doi.org/10.3389/fpsyt.2021.597725
2020
Thorpe, H. A., Talhat, A., Khokhar, J. Y. 2020. High genes: Genetic underpinnings of cannabis use phenotypes. Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2020.110164
Catharine A. Mielnik, Kim S. Sugamori, David B. Finlay, Hayley H. A. Thorpe, Matthieu Schapira, Nirunthan Sivananthan, Chun Kit Li, Vincent M. Lam, Sean Harrington, Mostafa H. Abdelrahman, Laurent A. Trembleau, W. McIntyre Burnham, Jibran Y. Khokhar, Ali Salahpour, Amy J. Ramsey, Michelle Glass, Iain R. Greig, Ruth A. Ross. 2020. A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology. https://doi-org.subzero.lib.uoguelph.ca/10.1038/s41386-020-00876-5
Hamidullah, S., Lutelmowski, C. D., Creighton, S. D., Luciani, K. R., Frie, J. A., Winters, B. D., Khokhar, J. 2020. Effects of vapourized THC and voluntary alcohol drinking during adolescence on cognition, reward, and anxiety-like behaviours in rats. Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2020.110141
Frie, J. A., Underhill, J., Zhao, B., Guglielmo, G., Tyndale, R. F., Khokhar, J. Y. 2020. OpenVape: an Open-Source E-Cigarette Vapour Exposure Device for Rodents. eNeuro. https://doi.org/10.1523/ENEURO.0279-20.2020
Renda, B., Andrade, A. K., Frie, J. A., Sgarbrossa, C. L., Murray, J. E., Khokhar, J. Y. 2020. High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats. Drug and Alcohol Dependence. https://doi.org/10.1016/j.drugalcdep.2020.108215
Hamidullah, S., Thorpe, H. A., Frie, J. A., Mccurdy, R. D., Khokhar, J. Y. 2020. Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates. Front. Hum. Neurosci. https://doi.org/10.3389/fnhum.2020.00298
Luciani, K. R., Frie, J. A., Khokhar, J. Y. 2020. An Open Source Automated Bar Test for Measuring Catalepsy in Rats. eNeuro. https://doi.org/10.1523/ENEURO.0488-19.2020
2019
Thorpe, H. A., Hamidullah, S., Jenkins, B. W., Khokhar, J. Y. 2019. Adolescent Neurodevelopment and Substance Use: Receptor Expression and Behavioral Consequences. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2019.107431
Nelong, T. F., Jenkins, B. W., Perreault, M. L., Khokhar, J. Y. 2019. Extended Attenuation of Corticostriatal Power and Coherence after Acute Exposure to Vapourized Δ9- Tetrahydrocannabinol in Rats. Canadian Journal of Addiction. 10(3): 60-66. doi: 10.1097/CXA.0000000000000063
Dwiel, L. L., Khokhar, J. Y., Connerney, M. A., Green, A. I., Doucette, W. T. 2019. Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats. PLOS Computational Biology. 15(4). https://doi.org/10.1371/journal.pcbi.1006838
Frie, J. A. and Khokhar, J. Y. 2019. An open source automated two-bottle choice test apparatus for rats. HardwareX. https://doi.org/10.1016/j.ohx.2019.e00061
2017
Green A. I. and Khokhar, J. Y. 2017. Addiction and Schizophrenia: A Translational Perspective. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.10.008
Whitfield-Gabrieli, S., Fischer, A. S., Henricks, A. M., Khokhar, J. Y., Roth, R. M., Brunette, M. F., Green, A. I. 2017. Understanding marijuana’s effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A Pilot Investigation. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.07.029
Khokhar, J. Y., Dwiel, L., Henricks, A., Doucette, W. T., Green, A. I. 2017. The Link Between Schizophrenia and Substance Use Disorder: A Unifying Hypothesis. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.04.016
Khokhar, J. Y. and Todd, T. P. 2017. Behavioral Predictors of Alcohol Drinking in a Neurodevelopmental Rat Model of Schizophrenia and Co-occurring Alcohol Use Disorder. Schizophrenia Res. http://dx.doi.org/10.1016/j.schres.2017.02.029
2016
Khokhar, J. Y., Green, A. I. 2016. Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster. Neuropharmacology. Jun;105:25-34.
2015
Doucette, W., Khokhar, J. Y., Green, A. I. 2015. Nucleus Accumbens deep brain stimulation in a rat model of binge eating. Transl. Psychiatry. 5, e695; doi:10.1038/tp.2015.197.
Chau, D. T., Khokhar, J. Y., Gulick, D., Dawson, R., Green, A. I. 2015. Desipramine enhances the ability of paliperidone to reduce alcohol drinking. J. Psych. Res. Oct; 69: 9–18.
Khokhar, J. Y., Chau, D. T., Dawson, R., Green, A. I. 2015. Clozapine reconstructed: Haloperidol’s ability to reduce alcohol Intake In the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan. Drug Alcohol Depen. July; 152:277–281.
2014
Gulick, D., Chau, D. T., Khokhar, J. Y., Dawson, R., Green, A. I. 2014. Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster. Psych. Res. Aug 30;218(3):329-34.
Khokhar, J. Y. and Tyndale, R. F. 2014. Intracerebroventricularly and Systemically Delivered Inhibitor of Brain Cyp2b (C8-Xanthate), Even Following Chlorpyrifos Exposure, Reduces Chlorpyrifos Activation and Toxicity in Male Rats. Toxicol. Sci. Jul;140(1):49-60.
2013
Chau, D.T., Khokhar, J. Y., Dawson, R., Ahmed, J., Xie, H., Green, A. I., 2013. The comparative effects of clozapine versus haloperidol on initiation and maintenance of alcohol drinking in male alcohol-preferring P rat. Alcohol. Dec;47(8):611-8.
Zhou, K., Khokhar, J. Y., Bin, Z., and Tyndale, R. F. 2013. First demonstration that CYP2D-mediated opiate metabolic activation alters analgesia in vivo. Biochem Pharmacol.15;85(12): 1848-55.
2012
Khokhar, J. Y. and Tyndale, R. F. 2012. Rat Brain Cyp2b-Enzymatic Activation Of Chlorpyrifos To The Oxon Mediates Cholinergic Neurotoxicity. Toxicol. Sci. 126(2):325-35.
2011
Khokhar, J.Y. and Tyndale, R.F 2011. Drug metabolism within the brain changes drug response: Selective manipulation of brain CYP2B alters propofol effects. Neuropsychopharmacology. 36(3):692-700.
2010
Khokhar, J. Y., Miksys, S., Tyndale, R. F. 2010. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain Res. 1348:1-9.
Khokhar, J. Y., Ferguson, C., Zhu, A., Tyndale, R. F. 2010. Pharmacogenetics of drug dependence: Role of gene variations in susceptibility and treatment. Annu. Rev. Pharmacol. Toxicol. 50:39-61.
2009
Yue J., Khokhar J. Y., Miksys S., Tyndale R. F. 2009. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. Eur. J. Pharmacol. 609: 88-95/