Publications

McCunn P, Chen X, Gimi B, Green AI, Khokhar JY. Glutamine and GABA alterations in cingulate cortex may underlie alcohol drinking in a rat model of co-occurring alcohol use disorder and schizophrenia: an 1H-MRS study. Schizophrenia (Heidelb). 2022 Aug 23;8(1):67. doi: 10.1038/s41537-022-00272-6.

Sikic A, Frie JA, Khokhar JY, Murray JE. Sex Differences in the Behavioural Outcomes of Prenatal Nicotine and Tobacco Exposure. Front Neurosci. 2022 Jul 8;16:921429. doi: 10.3389/fnins.2022.921429.

Henricks AM, Sullivan EDK, Dwiel LL, Li JY, Wallin DJ, Khokhar JY, Doucette WT. Maternal immune activation and adolescent alcohol exposure increase alcohol drinking and disrupt cortical-striatal-hippocampal oscillations in adult offspring. Transl Psychiatry. 2022 Jul 20;12(1):288. doi: 10.1038/s41398-022-02065-y.

Al-Sabagh Y, Thorpe HHA, Jenkins BW, Hamidullah S, Talhat MA, Suggett CB, Reitz CJ, Rasouli M, Martino TA, Khokhar JY. Rev-erbα Knockout Reduces Ethanol Consumption and Preference in Male and Female Mice. Int J Mol Sci. 2022 May 6;23(9):5197. doi: 10.3390/ijms23095197.

Doucette, W. T., Smedley, E. B., Ruiz-Jaquez, M., Khokhar, J. Y., Smith, K. S., Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet. Brain Res. 2022 June 1. https://doi.org/10.1016/j.brainres.2022.147886 

Quansah Amissah, R., Vogt, N. A., Chen, C., Urban, K., Khokhar, J. Y., Prevalence and characteristics of cannabis-induced toxicoses in pets: Results from a survey of veterinarians in North America. PLoS One. 2022 April 20. https://doi.org/10.1371/journal.pone.0261909 

Rizk, A. A., Jenkins, B. W., Al-Sabagh, Y., Hamidullah, S., Reitz, C. J., Rasouli, M., Martino, T. A., Khokhar, J. Y., The Impact of Sex, Circadian Disruption, and the Clock Δ19/Δ19 Genotype on Alcohol Drinking in Mice. Genes (Basel). 2022 April 15. https://doi.org/10.3390/genes13040701 

Kayir, H., Jenkins, B. W., Alural, B., Khokhar, J. Y., Clozapine Increases Nestin Concentration in the Adult Male Rat Hippocampus: A Preliminary Study. Int J Mol Sci. 2022 March 22. https://doi.org/10.3390/ijms23073436 

Ruffolo, J., Frie, J. A., Thorpe, H. H. H., Talhat, M. A., Khokhar, J. Y., Alcohol and Vaporized Nicotine Co-Exposure During Adolescence Contribute Differentially to Sex-Specific Behavioral Effects in Adulthood. Nicotine Tob. Res. 2021 December 3. https://doi.org/10.1093/ntr/ntab250 

Jenkins, B. W., Buckhalter, S., Perreault, M. L., Khokhar, J. Y., Cannabis Vapour Exposure Alters Neural Circuit Oscillatory Activity in A Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents. Schizophr. Bull. 2021 November 20. https://doi.org/10.1093/schizbullopen/sgab052   

Sullivan, E. D.K., Locke, L. N., Wallin, D. J., Khokhar, J. Y., Bragg, E. M., Henricks, A. M., Doucette, W. T., The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat. Front Behav Neurosci. 2021 November 11. https://doi.org/10.3389/fnbeh.2021.760791 

Frie, J. A., Nolan, C. J., Murray, J. E., Khokhar, J. Y., Addiction-Related Outcomes of Nicotine and Alcohol Co-use: New Insights Following the Rise in Vaping. Nicotine Tob Res. 2021 Nov 10. https://doi.org/10.1093/ntr/ntab231 

Ellner, D., Hallam, B., Frie, J. A., Thorpe, H. H. A., Shoaib, M., Kayir, H., Jenkins, B. W., Khokhar, J. Y., Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism during Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats. Front Synaptic Neurosci. 2021 https://doi.org/10.3389/fnsyn.2021.732402 

Wallin, D. J., Sullivan, E. D. K., Bragg, E. M., Khokhar, J. Y., Lu, H., Doucette, W. T., Acquisition of resting-state functional magnetic resonance imaging data in the rat. J Vis Exp. 2021 https://dx.doi.org/10.3791/62596 

Buckhalter, S., Soubeyrand, E., Ferrone, S. A. E., Rasmussen, D. J., Manduca, J. D., Al-Abdul Wahid, S., Frie, J. A., Khokhar, J. Y., Akhtar, T. A., Perreault, M. L., The antidepressant-like and analgesic effects of kratom alkaloids are accompanied by changes in low frequency oscillations but not ΔFosB accumulation. Front Pharmacol 2021; 12: 696461. https://doi.org/10.3389/fphar.2021.696461 

McKie, G. L., Shamshoum, H., Hunt, K. L., Thorpe, H. H. A., Dibe, H. A., Khokhar, J. Y., Doucette, C. A., Wright, D. C., Intermittent Cold Exposure Improves Glucose Homeostasis Despite Exacerbating Diet-Induced Obesity in Mice Housed at Thermoneutrality. J Physiol. 2021 Jun 30. https://doi.org/10.1113/JP281774 

Theriault, R. K., St-Denis, M., Hewitt, T., Khokhar, J. Y., Lalonde, J., Perreault, M. L., Sex-specific cannabidiol- and iloperidone-induced neuronal activity changes in an in vitro MAM model system of schizophrenia. Int J Mol Sciences. 2021 May 24;22(11):5511. https://doi.org/10.3390/ijms22115511 

Oleson E. B., KhokharJ. Y. Cannabinoids: Emerging developments in neuropsychopharmacology and biological psychiatry. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 15:110305. https://doi.org/10.1016/j.pnpbp.2021.110305 

Renda, B., Andrade, A., Stone, A. P., El Azali, R., Sharivker, M., Khokhar, J. Y., Antenos, M., Murray, J. E., Adolescent nicotine and footshock exposure augments adult nicotine self-administration and drug-seeking without affecting baseline anxiety-like behaviour or stress responsivity in male rats. Psychopharmacology 2021 Mar 1. https://doi.org/10.1007/s00213-021-05803-0 

Misner, M., Taborek, A., Dufour, J., Sharifi, L., Khokhar, J. Y., Favetta, L. A., 2021, Effects of delta-9 tetrahydrocannabinol (THC) on oocyte competence and early embryonic development. Front. Toxicol. 23 March 2021 https://doi.org/10.3389/ftox.2021.647918  

Jenkins, B. W., Khokhar, J. Y. 2021. Cannabis use and mental illness: understanding circuit dysfunction through preclinical models. Front. Psychiatry. https://doi.org/10.3389/fpsyt.2021.597725

Thorpe, H. A., Talhat, A., Khokhar, J. Y. 2020. High genes: Genetic underpinnings of cannabis use phenotypes. Progress in Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2020.110164

Catharine A. Mielnik, Kim S. Sugamori, David B. Finlay, Hayley H. A. Thorpe, Matthieu Schapira, Nirunthan Sivananthan, Chun Kit Li, Vincent M. Lam, Sean Harrington, Mostafa H. Abdelrahman, Laurent A. Trembleau, W. McIntyre Burnham, Jibran Y. Khokhar, Ali Salahpour, Amy J. Ramsey, Michelle Glass, Iain R. Greig, Ruth A. Ross. 2020. A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology. https://doi-org.subzero.lib.uoguelph.ca/10.1038/s41386-020-00876-5

Hamidullah, S., Lutelmowski, C. D., Creighton, S. D., Luciani, K. R., Frie, J. A., Winters, B. D., Khokhar, J. 2020. Effects of vapourized THC and voluntary alcohol drinking during adolescence on cognition, reward, and anxiety-like behaviours in rats. Neuro-Psychopharmacology and Biological Psychiatry. https://doi.org/10.1016/j.pnpbp.2020.110141

Frie, J. A., Underhill, J., Zhao, B., Guglielmo, G., Tyndale, R. F., Khokhar, J. Y. 2020. OpenVape: an Open-Source E-Cigarette Vapour Exposure Device for Rodents. eNeuro. https://doi.org/10.1523/ENEURO.0279-20.2020 

Renda, B., Andrade, A. K., Frie, J. A., Sgarbrossa, C. L., Murray, J. E., Khokhar, J. Y. 2020. High-dose adolescent nicotine exposure permits spontaneous nicotine self-administration in adult male rats. Drug and Alcohol Dependence. https://doi.org/10.1016/j.drugalcdep.2020.108215 

Hamidullah, S., Thorpe, H. A., Frie, J. A., Mccurdy, R. D., Khokhar, J. Y. 2020. Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates. Front. Hum. Neurosci. https://doi.org/10.3389/fnhum.2020.00298 

Luciani, K. R., Frie, J. A., Khokhar, J. Y. 2020. An Open Source Automated Bar Test for Measuring Catalepsy in Rats. eNeuro. https://doi.org/10.1523/ENEURO.0488-19.2020

Thorpe, H. A., Hamidullah, S., Jenkins, B. W., Khokhar, J. Y. 2019. Adolescent Neurodevelopment and Substance Use: Receptor Expression and Behavioral Consequences. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2019.107431

Nelong, T. F., Jenkins, B. W., Perreault, M. L., Khokhar, J. Y. 2019. Extended Attenuation of Corticostriatal Power and Coherence after Acute Exposure to Vapourized Δ9- Tetrahydrocannabinol in Rats. Canadian Journal of Addiction. 10(3): 60-66. doi: 10.1097/CXA.0000000000000063

Dwiel, L. L., Khokhar, J. Y., Connerney, M. A., Green, A. I., Doucette, W. T. 2019. Finding the balance between model complexity and performance: Using ventral striatal oscillations to classify feeding behavior in rats. PLOS Computational Biology. 15(4). https://doi.org/10.1371/journal.pcbi.1006838

Frie, J. A. and Khokhar, J. Y. 2019. An open source automated two-bottle choice test apparatus for rats. HardwareX. https://doi.org/10.1016/j.ohx.2019.e00061

Green A. I. and Khokhar, J. Y. 2017. Addiction and Schizophrenia: A Translational Perspective. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.10.008

Whitfield-Gabrieli, S., Fischer, A. S., Henricks, A. M., Khokhar, J. Y., Roth, R. M., Brunette, M. F., Green, A. I. 2017. Understanding marijuana’s effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A Pilot Investigation. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.07.029

Khokhar, J. Y., Dwiel, L., Henricks, A., Doucette, W. T., Green, A. I. 2017.  The Link Between Schizophrenia and Substance Use Disorder: A Unifying Hypothesis. Schizophrenia Res. http://doi.org/10.1016/j.schres.2017.04.016

Khokhar, J. Y. and Todd, T. P. 2017. Behavioral Predictors of Alcohol Drinking in a Neurodevelopmental Rat Model of Schizophrenia and Co-occurring Alcohol Use Disorder. Schizophrenia Res. http://dx.doi.org/10.1016/j.schres.2017.02.029

Khokhar, J. Y., Green, A. I. 2016. Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster. Neuropharmacology. Jun;105:25-34.

Doucette, W., Khokhar, J. Y., Green, A. I. 2015. Nucleus Accumbens deep brain stimulation in a rat model of binge eating. Transl. Psychiatry. 5, e695; doi:10.1038/tp.2015.197.

Chau, D. T., Khokhar, J. Y., Gulick, D., Dawson, R., Green, A. I. 2015. Desipramine enhances the ability of paliperidone to reduce alcohol drinking. J. Psych. Res. Oct; 69: 9–18.

Khokhar, J. Y., Chau, D. T., Dawson, R., Green, A. I. 2015. Clozapine reconstructed: Haloperidol’s ability to reduce alcohol Intake In the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan. Drug Alcohol Depen. July; 152:277–281.

Gulick, D., Chau, D. T., Khokhar, J. Y., Dawson, R., Green, A. I. 2014. Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster. Psych. Res. Aug 30;218(3):329-34.

Khokhar, J. Y. and Tyndale, R. F. 2014. Intracerebroventricularly and Systemically Delivered Inhibitor of Brain Cyp2b (C8-Xanthate), Even Following Chlorpyrifos Exposure, Reduces Chlorpyrifos Activation and Toxicity in Male Rats. Toxicol. Sci. Jul;140(1):49-60.

Chau, D.T., Khokhar, J. Y., Dawson, R., Ahmed, J., Xie, H., Green, A. I., 2013. The comparative effects of clozapine versus haloperidol on initiation and maintenance of alcohol drinking in male alcohol-preferring P rat. Alcohol. Dec;47(8):611-8.

Zhou, K., Khokhar, J. Y., Bin, Z., and Tyndale, R. F. 2013. First demonstration that CYP2D-mediated opiate metabolic activation alters analgesia in vivo. Biochem Pharmacol.15;85(12): 1848-55.

Khokhar, J. Y. and Tyndale, R. F. 2012. Rat Brain Cyp2b-Enzymatic Activation Of Chlorpyrifos To The Oxon Mediates Cholinergic Neurotoxicity.  Toxicol. Sci. 126(2):325-35. 

Khokhar, J.Y. and Tyndale, R.F 2011. Drug metabolism within the brain changes drug response: Selective manipulation of brain CYP2B alters propofol effects. Neuropsychopharmacology. 36(3):692-700. 

Khokhar, J. Y., Miksys, S., Tyndale, R. F. 2010. Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors. Brain Res. 1348:1-9. 

Khokhar, J. Y., Ferguson, C., Zhu, A., Tyndale, R. F. 2010. Pharmacogenetics of drug dependence: Role of gene variations in susceptibility and treatment. Annu. Rev. Pharmacol. Toxicol. 50:39-61.

Yue J., Khokhar J. Y., Miksys S., Tyndale R. F. 2009. Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake. Eur. J. Pharmacol. 609: 88-95/